Annotation Detail

Information
Associated Genes
PTEN
Associated Variants
PTEN p.Tyr178_Ser179delinsTerCys (p.Y178_S179delins*C) ( ENST00000688308.1, ENST00000700029.2, ENST00000371953.8, ENST00000713839.1, ENST00000700021.1, ENST00000472832.3 )
PTEN p.Tyr178_Ser179delinsTerCys (p.Y178_S179delins*C) ( ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2, ENST00000713839.1 )
Associated Disease
Cowden syndrome 1
Source Database
ClinVar
Description
NM_000314.8(PTEN):c.534_535delinsAT (p.Tyr178_Ser179delinsTer) AND Cowden syndrome 1
ClinVar Allele ID
22863
ClinVar RefSeq Alternation Syntax
NM_001304718.2:c.-58_-57delinsAT
ClinVar RefSeq Alternation Syntax
NM_000314.8:c.534_535delinsAT
ClinVar RefSeq Alternation Syntax
NM_001304717.5:c.1053_1054delinsAT
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1998-11-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000008270
ClinVar Disease
Cowden syndrome 1
Observed Origin Sample
germline
Pubmed
9832032
Drugs