Annotation Detail

Information
Associated Genes
PTEN
Associated Variants
PTEN p.Arg233Ter (p.R233*) ( ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2, ENST00000713839.1 )
PTEN p.Arg233Ter (p.R233*) ( ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2, ENST00000713839.1 )
Associated Disease
Cowden syndrome 1
Source Database
ClinVar
Description
NM_000314.8(PTEN):c.697C>T (p.Arg233Ter) AND Cowden syndrome 1
ClinVar Allele ID
22852
ClinVar RefSeq Alternation Syntax
NM_001304718.2:c.106C>T
ClinVar RefSeq Alternation Syntax
NM_001304717.5:c.1216C>T
ClinVar RefSeq Alternation Syntax
NM_000314.8:c.697C>T
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2024-03-25
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000008256
ClinVar Disease
Cowden syndrome 1
Observed Origin Sample
germline
Observed Origin Sample
de novo
Observed Origin Sample
unknown
Pubmed
1336932
Pubmed
9241266
Pubmed
27426521
Pubmed
9140396
Drugs