Annotation Detail

Information
Associated Genes
POLR2F SOX10
Associated Variants
SOX10 p.Ser135Thr (p.S135T), POLR2F c.294-2773C>G ( ENST00000405557.5, ENST00000407936.5, ENST00000360880.6, ENST00000396884.8, ENST00000698177.1 )
SOX10 p.Ser135Thr (p.S135T), POLR2F c.294-2773C>G ( ENST00000405557.5, ENST00000407936.5, ENST00000360880.6, ENST00000396884.8, ENST00000698177.1 )
Associated Disease
Waardenburg syndrome type 2E, without neurologic involvement
Source Database
ClinVar
Description
NM_006941.4(SOX10):c.404G>C (p.Ser135Thr) AND Waardenburg syndrome type 2E, without neurologic involvement
ClinVar Allele ID
22436
ClinVar RefSeq Alternation Syntax
NM_001363825.1:c.*38+11071C>G
ClinVar RefSeq Alternation Syntax
NM_001301131.2:c.293+16211C>G
ClinVar RefSeq Alternation Syntax
NM_001301130.2:c.294-2773C>G
ClinVar RefSeq Alternation Syntax
NM_006941.4:c.404G>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1999-09-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000007821
ClinVar Disease
Waardenburg syndrome type 2E, without neurologic involvement
Observed Origin Sample
germline
Pubmed
10441344
Pubmed
8911608
Drugs