Annotation Detail

Information
Associated Genes
SPG7
Associated Variants
SPG7 p.Trp583Cys (p.W583C) ( ENST00000643649.1, ENST00000647079.1, ENST00000646303.1, ENST00000268704.7, ENST00000645063.1, ENST00000645818.2, ENST00000644781.1, ENST00000646716.1, ENST00000645897.1 )
SPG7 p.Trp583Cys (p.W583C) ( ENST00000268704.7, ENST00000643649.1, ENST00000644781.1, ENST00000645063.1, ENST00000645818.2, ENST00000645897.1, ENST00000646303.1, ENST00000646716.1, ENST00000647079.1 )
Associated Disease
hereditary spastic paraplegia 7
Source Database
ClinVar
Description
NM_003119.4(SPG7):c.1749G>C (p.Trp583Cys) AND Hereditary spastic paraplegia 7
ClinVar Allele ID
21859
ClinVar RefSeq Alternation Syntax
NM_003119.4:c.1749G>C
ClinVar RefSeq Alternation Syntax
NM_001363850.1:c.1749G>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-01-20
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000007222
ClinVar Disease
Hereditary spastic paraplegia 7
Observed Origin Sample
germline
Observed Origin Sample
unknown
Pubmed
20186691
Drugs