Annotation Detail

Information
Associated Genes
DHCR7
Associated Variants
DHCR7 p.Trp248Cys (p.W248C) ( ENST00000685320.1, ENST00000682708.1, ENST00000683714.1, ENST00000526780.6, ENST00000682880.1, ENST00000407721.6, ENST00000527316.6, ENST00000683287.1, ENST00000355527.8 )
DHCR7 p.Trp248Cys (p.W248C) ( ENST00000355527.8, ENST00000407721.6, ENST00000526780.6, ENST00000527316.6, ENST00000682708.1, ENST00000682880.1, ENST00000683287.1, ENST00000683714.1, ENST00000685320.1 )
Associated Disease
Smith-Lemli-Opitz syndrome
Source Database
ClinVar
Description
NM_001360.3(DHCR7):c.744G>T (p.Trp248Cys) AND Smith-Lemli-Opitz syndrome
ClinVar Allele ID
21821
ClinVar RefSeq Alternation Syntax
NM_001163817.2:c.744G>T
ClinVar RefSeq Alternation Syntax
NM_001360.3:c.744G>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2000-02-14
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000007184
ClinVar Disease
Smith-Lemli-Opitz syndrome
Observed Origin Sample
germline
Pubmed
10710236
Pubmed
9683613
Drugs