Annotation Detail

Information
Associated Genes
MUTYH
Associated Variants
MUTYH p.Tyr101Ter (p.Y101*), ENSG00000288208 p.Tyr272Ter (p.Y272*) ( ENST00000355498.6, ENST00000412971.6, ENST00000528013.6, ENST00000372104.5, ENST00000354383.10, ENST00000456914.7, ENST00000483127.2, ENST00000672314.2, ENST00000372115.7, ENST00000529984.5, ENST00000488731.6, ENST00000713751.1, ENST00000529892.6, ENST00000372098.7, ENST00000448481.5, ENST00000672818.3, ENST00000531105.5, ENST00000372110.7, ENST00000713750.1, ENST00000710952.2 )
MUTYH p.Tyr101Ter (p.Y101*), ENSG00000288208 p.Tyr272Ter (p.Y272*) ( ENST00000354383.10, ENST00000355498.6, ENST00000372098.7, ENST00000372104.5, ENST00000372110.7, ENST00000372115.7, ENST00000412971.6, ENST00000448481.5, ENST00000456914.7, ENST00000483127.2, ENST00000488731.6, ENST00000528013.6, ENST00000529892.6, ENST00000529984.5, ENST00000531105.5, ENST00000672314.2, ENST00000672818.3, ENST00000710952.2, ENST00000713750.1, ENST00000713751.1 )
Associated Disease
familial adenomatous polyposis 2
Source Database
ClinVar
Description
NM_001048174.2(MUTYH):c.228C>A (p.Tyr76Ter) AND Familial adenomatous polyposis 2
ClinVar Allele ID
20335
ClinVar RefSeq Alternation Syntax
NM_001293192.2:c.-49C>A
ClinVar RefSeq Alternation Syntax
NR_146882.2:n.456C>A
ClinVar RefSeq Alternation Syntax
NM_001293196.2:c.-49C>A
ClinVar RefSeq Alternation Syntax
NM_001350651.2:c.-44C>A
ClinVar RefSeq Alternation Syntax
NM_001048174.2:c.228C>A
ClinVar RefSeq Alternation Syntax
NM_001048171.2:c.228C>A
ClinVar RefSeq Alternation Syntax
NR_146883.2:n.379C>A
ClinVar RefSeq Alternation Syntax
NM_012222.3:c.303C>A
ClinVar RefSeq Alternation Syntax
NM_001128425.2:c.312C>A
ClinVar RefSeq Alternation Syntax
NM_001293191.2:c.261C>A
ClinVar RefSeq Alternation Syntax
NM_001293195.2:c.228C>A
ClinVar RefSeq Alternation Syntax
NM_001048172.2:c.231C>A
ClinVar RefSeq Alternation Syntax
NM_001048173.2:c.228C>A
ClinVar RefSeq Alternation Syntax
NM_001293190.2:c.273C>A
ClinVar RefSeq Alternation Syntax
NM_001350650.2:c.-44C>A
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2024-01-19
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000005617
ClinVar Disease
Familial adenomatous polyposis 2
Observed Origin Sample
germline
Observed Origin Sample
inherited
Observed Origin Sample
unknown
Pubmed
12393807
Drugs