Annotation Detail

Information
Associated Genes
OPA1
Associated Variants
OPA1 p.Tyr619Cys (p.Y619C) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
OPA1 p.Tyr619Cys (p.Y619C) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
Associated Disease
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
Source Database
ClinVar
Description
NM_130837.3(OPA1):c.1910A>G (p.Tyr637Cys) AND Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
ClinVar Allele ID
20129
ClinVar RefSeq Alternation Syntax
NM_130831.3:c.1637A>G
ClinVar RefSeq Alternation Syntax
NM_130832.3:c.1691A>G
ClinVar RefSeq Alternation Syntax
NM_001354663.2:c.1376A>G
ClinVar RefSeq Alternation Syntax
NM_015560.3:c.1745A>G
ClinVar RefSeq Alternation Syntax
NM_130835.3:c.1802A>G
ClinVar RefSeq Alternation Syntax
NM_130833.3:c.1748A>G
ClinVar RefSeq Alternation Syntax
NM_130836.3:c.1856A>G
ClinVar RefSeq Alternation Syntax
NM_130834.3:c.1799A>G
ClinVar RefSeq Alternation Syntax
NM_130837.3:c.1910A>G
ClinVar RefSeq Alternation Syntax
NM_001354664.2:c.1373A>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2008-01-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000005395
ClinVar Disease
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
Observed Origin Sample
germline
Pubmed
18195150
Drugs