Annotation Detail

Information
Associated Genes
OPA1
Associated Variants
OPA1 p.Val940GlyfsTer3 (p.V940Gfs*3) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
OPA1 p.Val940GlyfsTer3 (p.V940Gfs*3) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
Associated Disease
Autosomal dominant optic atrophy classic form
Source Database
ClinVar
Description
NM_130837.3(OPA1):c.2873_2876del AND Autosomal dominant optic atrophy classic form
ClinVar Allele ID
20121
ClinVar RefSeq Alternation Syntax
NM_130837.3:c.2873_2876del
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2023-08-23
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000005387
ClinVar Disease
Autosomal dominant optic atrophy classic form
Observed Origin Sample
germline
Observed Origin Sample
maternal
Observed Origin Sample
unknown
Pubmed
11440989
Pubmed
21636302
Pubmed
11017079
Pubmed
25012220
Pubmed
9917792
Pubmed
9490303
Drugs