Annotation Detail

Information
Associated Genes
FOXP2
Associated Variants
FOXP2 p.Arg578His (p.R578H) ( ENST00000350908.9, ENST00000393494.6, ENST00000393498.6, ENST00000403559.9, ENST00000408937.7, ENST00000634411.1, ENST00000635534.1, ENST00000635638.1, ENST00000703612.1, ENST00000703613.1, ENST00000703614.1, ENST00000703616.1 )
FOXP2 p.Arg578His (p.R578H) ( ENST00000350908.9, ENST00000393494.6, ENST00000393498.6, ENST00000403559.9, ENST00000408937.7, ENST00000634411.1, ENST00000635534.1, ENST00000635638.1, ENST00000703612.1, ENST00000703613.1, ENST00000703614.1, ENST00000703616.1 )
Associated Disease
Childhood apraxia of speech
Source Database
ClinVar
Description
NM_014491.4(FOXP2):c.1658G>A (p.Arg553His) AND Childhood apraxia of speech
ClinVar Allele ID
20106
ClinVar RefSeq Alternation Syntax
NM_148898.4:c.1733G>A
ClinVar RefSeq Alternation Syntax
NM_148900.4:c.1709G>A
ClinVar RefSeq Alternation Syntax
NM_001172766.3:c.1655G>A
ClinVar RefSeq Alternation Syntax
NM_014491.4:c.1658G>A
ClinVar RefSeq Alternation Syntax
NR_033766.2:n.2026G>A
ClinVar RefSeq Alternation Syntax
NR_033767.2:n.2272G>A
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2022-10-26
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000005371
ClinVar Disease
Childhood apraxia of speech
Observed Origin Sample
germline
Observed Origin Sample
de novo
Observed Origin Sample
unknown
Pubmed
2332125
Pubmed
22434823
Pubmed
11586359
Pubmed
20858596
Drugs