Annotation Detail

Information
Associated Genes
GHRL GHRLOS
Associated Variants
GHRL p.Leu72Met (p.L72M) ( ENST00000287656.11, ENST00000335542.13, ENST00000422159.5, ENST00000429122.1, ENST00000430179.5, ENST00000437422.6, ENST00000439975.6, ENST00000446937.2, ENST00000449238.6, ENST00000457360.5 )
GHRL p.Leu72Met (p.L72M) ( ENST00000287656.11, ENST00000335542.13, ENST00000422159.5, ENST00000429122.1, ENST00000430179.5, ENST00000437422.6, ENST00000439975.6, ENST00000446937.2, ENST00000449238.6, ENST00000457360.5 )
Associated Disease
Obesity, age at onset of
Source Database
ClinVar
Description
NM_016362.5(GHRL):c.214C>A (p.Leu72Met) AND Obesity, age at onset of
ClinVar Allele ID
20101
ClinVar RefSeq Alternation Syntax
NM_001134944.2:c.178C>A
ClinVar RefSeq Alternation Syntax
NM_001134941.3:c.211C>A
ClinVar RefSeq Alternation Syntax
NM_001302824.2:c.214C>A
ClinVar RefSeq Alternation Syntax
NM_001134945.2:c.175C>A
ClinVar RefSeq Alternation Syntax
NM_001302822.2:c.214C>A
ClinVar RefSeq Alternation Syntax
NM_001302825.2:c.214C>A
ClinVar RefSeq Alternation Syntax
NM_001302821.2:c.214C>A
ClinVar RefSeq Alternation Syntax
NM_016362.5:c.214C>A
ClinVar RefSeq Alternation Syntax
NM_001134946.2:c.73-2961C>A
ClinVar RefSeq Alternation Syntax
NM_001302823.2:c.211C>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2005-12-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000005365
ClinVar Disease
Obesity, age at onset of
Observed Origin Sample
germline
Pubmed
12050239
Pubmed
16204371
Pubmed
11502844
Pubmed
12161552
Drugs