Annotation Detail

Information
Associated Genes
KCNQ1
Associated Variants
KCNQ1 p.Gln544ValfsTer108 (p.Q544Vfs*108) ( ENST00000713725.1, ENST00000646564.2, ENST00000335475.6, ENST00000155840.12, ENST00000496887.7 )
KCNQ1 p.Gln544ValfsTer108 (p.Q544Vfs*108) ( ENST00000155840.12, ENST00000335475.6, ENST00000496887.7, ENST00000646564.2, ENST00000713725.1 )
Associated Disease
Jervell and Lange-Nielsen syndrome 1
Source Database
ClinVar
Description
NM_000218.3(KCNQ1):c.1630_1635delinsGTTGAGA (p.Gln544fs) AND Jervell and Lange-Nielsen syndrome 1
ClinVar Allele ID
67667
ClinVar RefSeq Alternation Syntax
NM_001406836.1:c.1534_1539delCAGTACinsGTTGAGA
ClinVar RefSeq Alternation Syntax
NM_001406837.1:c.1360_1365delCAGTACinsGTTGAGA
ClinVar RefSeq Alternation Syntax
NM_181798.2:c.1249_1254delCAGTACinsGTTGAGA
ClinVar RefSeq Alternation Syntax
NM_000218.3:c.1630_1635delinsGTTGAGA
ClinVar RefSeq Alternation Syntax
NM_001406838.1:c.1090_1095delCAGTACinsGTTGAGA
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1997-02-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000003272
ClinVar Disease
Jervell and Lange-Nielsen syndrome 1
Observed Origin Sample
germline
Pubmed
9020846
Drugs