Annotation Detail

Information
Associated Genes
SMPD1
Associated Variants
SMPD1 p.Gly579Ser (p.G579S) ( ENST00000342245.9, ENST00000527275.5 )
SMPD1 p.Gly579Ser (p.G579S) ( ENST00000342245.9, ENST00000527275.5 )
Associated Disease
Niemann-Pick disease, type A
Source Database
ClinVar
Description
NM_000543.5(SMPD1):c.1735G>A (p.Gly579Ser) AND Niemann-Pick disease, type A
ClinVar Allele ID
18021
ClinVar RefSeq Alternation Syntax
NM_001007593.3:c.1732G>A
ClinVar RefSeq Alternation Syntax
NM_000543.5:c.1735G>A
ClinVar RefSeq Alternation Syntax
NM_001318088.2:c.814G>A
ClinVar RefSeq Alternation Syntax
NM_001365135.2:c.1603G>A
ClinVar RefSeq Alternation Syntax
NR_027400.3:n.1688G>A
ClinVar RefSeq Alternation Syntax
NM_001318087.2:c.*228G>A
ClinVar RefSeq Alternation Syntax
NR_134502.2:n.1227G>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000003116
ClinVar Disease
Niemann-Pick disease, type A
Observed Origin Sample
germline
Pubmed
1718266
Drugs