Annotation Detail

Information
Associated Genes
VHL LOC107303340
Associated Variants
VHL p.Arg200Trp (p.R200W) ( ENST00000256474.3, ENST00000345392.3, ENST00000696143.2, ENST00000696153.1, ENST00000713811.1, ENST00000713812.1, ENST00000713815.1, ENST00000713982.1 )
VHL p.Arg200Trp (p.R200W) ( ENST00000256474.3, ENST00000345392.3, ENST00000696143.2, ENST00000696153.1, ENST00000713811.1, ENST00000713812.1, ENST00000713815.1, ENST00000713982.1 )
Associated Disease
Chuvash polycythemia
Source Database
ClinVar
Description
NM_000551.4(VHL):c.598C>T (p.Arg200Trp) AND Chuvash polycythemia
ClinVar Allele ID
17271
ClinVar RefSeq Alternation Syntax
NM_198156.3:c.475C>T
ClinVar RefSeq Alternation Syntax
NM_000551.4:c.598C>T
ClinVar RefSeq Alternation Syntax
NM_001354723.2:c.*152C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-03-23
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000002320
ClinVar Disease
Chuvash polycythemia
Observed Origin Sample
germline
Pubmed
12702509
Pubmed
16210343
Pubmed
12415268
Pubmed
11987242
Pubmed
14604959
Pubmed
14726398
Pubmed
9399847
Pubmed
15642664
Pubmed
12844285
Pubmed
21685897
Pubmed
10364675
Pubmed
23403324
Drugs