Annotation Detail

Information
Associated Genes
GLB1
Associated Variants
GLB1 p.Tyr591Cys (p.Y591C) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
GLB1 p.Tyr591Cys (p.Y591C) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
Associated Disease
GM1-gangliosidosis, type I, with cardiac involvement
Source Database
ClinVar
Description
NM_000404.4(GLB1):c.1772A>G (p.Tyr591Cys) AND GM1-gangliosidosis, type I, with cardiac involvement
ClinVar Allele ID
15987
ClinVar RefSeq Alternation Syntax
NM_001079811.3:c.1682A>G
ClinVar RefSeq Alternation Syntax
NM_000404.4:c.1772A>G
ClinVar RefSeq Alternation Syntax
NM_001135602.3:c.1379A>G
ClinVar RefSeq Alternation Syntax
NM_001317040.2:c.1916A>G
ClinVar RefSeq Alternation Syntax
NM_001393580.1:c.1734+16749A>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2000-01-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000000998
ClinVar Disease
GM1-gangliosidosis, type I, with cardiac involvement
Observed Origin Sample
germline
Pubmed
10737981
Drugs