Annotation Detail

Information
Associated Genes
GLB1
Associated Variants
GLB1 p.Arg457Gln (p.R457Q) ( ENST00000307377.12, ENST00000399402.7, ENST00000307363.10 )
GLB1 p.Arg457Gln (p.R457Q) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
Associated Disease
GM1 gangliosidosis type 3
Source Database
ClinVar
Description
NM_000404.4(GLB1):c.1370G>A (p.Arg457Gln) AND GM1 gangliosidosis type 3
ClinVar Allele ID
15969
ClinVar RefSeq Alternation Syntax
NM_000404.4:c.1370G>A
ClinVar RefSeq Alternation Syntax
NM_001135602.3:c.977G>A
ClinVar RefSeq Alternation Syntax
NM_001079811.3:c.1280G>A
ClinVar RefSeq Alternation Syntax
NM_001393580.1:c.1370G>A
ClinVar RefSeq Alternation Syntax
NM_001317040.2:c.1514G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1991-08-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000000978
ClinVar Disease
GM1 gangliosidosis type 3
Observed Origin Sample
germline
Pubmed
1907800
Drugs