Annotation Detail

Information
Associated Genes
GLB1
Associated Variants
GLB1 p.Tyr316Cys (p.Y316C) ( ENST00000307377.12, ENST00000399402.7, ENST00000307363.10 )
GLB1 p.Tyr316Cys (p.Y316C) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
Associated Disease
Infantile GM1 gangliosidosis
Source Database
ClinVar
Description
NM_000404.4(GLB1):c.947A>G (p.Tyr316Cys) AND Infantile GM1 gangliosidosis
ClinVar Allele ID
15968
ClinVar RefSeq Alternation Syntax
NM_001317040.2:c.1091A>G
ClinVar RefSeq Alternation Syntax
NM_000404.4:c.947A>G
ClinVar RefSeq Alternation Syntax
NM_001079811.3:c.857A>G
ClinVar RefSeq Alternation Syntax
NM_001135602.3:c.554A>G
ClinVar RefSeq Alternation Syntax
NM_001393580.1:c.947A>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1992-05-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000000977
ClinVar Disease
Infantile GM1 gangliosidosis
Observed Origin Sample
germline
Pubmed
1606711
Pubmed
1907800
Drugs