Annotation Detail
Information
- Associated Genes
- STAG2
- Associated Variants
-
STAG2 UNDEREXPRESSION
(
ENST00000371157.7 )
STAG2 UNDEREXPRESSION ( ENST00000371157.7 ) - Associated Disease
- bladder carcinoma
- Source Database
- CIViC Evidence
- Description
- Tumor samples from 125 patients with bladder cancer were assessed by IHC for STAG2 expression. STAG2-negativity was associated with lower histological grade (p = 0.009). Complete loss of STAG2 expression was associated with a lower risk of recurrence (P = 0.023) and diminished risk of death (P = 0.034) in log-rank analysis and was a beneficial factor in uni- and multivariate analysis.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/984
- Gene URL
- https://civic.genome.wustl.edu/links/genes/8553
- Variant URL
- https://civic.genome.wustl.edu/links/variants/422
- Rating
- 2
- Evidence Type
- Prognostic
- Disease
- Bladder Carcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Better Outcome
- Pubmed
- 26838030
Drugs