Annotation Detail
Information
- Associated Genes
- TERT
- Associated Variants
-
TERT c.1574-3777G>T
(
ENST00000310581.10,
ENST00000334602.10 )
TERT c.1574-3777G>T ( ENST00000310581.10, ENST00000334602.10 ) - Associated Disease
- brain glioma
- Source Database
- CIViC Evidence
- Description
- Meta-analysis of 10 studies (9,411 patients, 13,708 controls) showed that TERT polymorphisms (rs2736100) were associated with an increased glioma risk (RR=1.28, 95% CI 1.23-1.33).
- Variant Origin
- Common Germline
- Variant Origin
- Common Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/980
- Gene URL
- https://civic.genome.wustl.edu/links/genes/79
- Variant URL
- https://civic.genome.wustl.edu/links/variants/421
- Rating
- 2
- Evidence Type
- Predisposing
- Disease
- Brain Glioma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Positive
- Pubmed
- 26765760
Drugs