Annotation Detail

Information
Associated Genes
NTRK1
Associated Variants
NTRK1 NTRK1 FUSIONS NTRK1 NTRK1 FUSIONS
Associated Disease
colorectal cancer
Source Database
CIViC Evidence
Description
NTRK1 fusions (one LMNA-NTRK1 and two TPM3-NTRK1) were identified in 2% of Korean colorectal cancer patients (147 patients). TrkA (NTRK1) protein expression was associated with presence of NTRK1 gene fusion. These fusions were mutually exclusive with other oncogenic drivers and showed in-vitro sensitivity to TrkA Inhibitor ARRY470 (Larotrectinib) (one cell line with fusion (KM12), one control cell line).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/978
Gene URL
https://civic.genome.wustl.edu/links/genes/3983
Variant URL
https://civic.genome.wustl.edu/links/variants/419
Rating
2
Evidence Type
Predictive
Disease
Colorectal Cancer
Evidence Direction
Supports
Drug
Larotrectinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
26716414
Drugs
Drug NameSensitivitySupported
LarotrectinibSensitivitytrue