Annotation Detail
Information
- Associated Genes
- POU5F1
- Associated Variants
-
POU5F1 EXPRESSION
POU5F1 EXPRESSION - Associated Disease
- colon cancer
- Source Database
- CIViC Evidence
- Description
- OCT4B1 (POU5F1 splice variant) expression reduced sensitivity to oxaliplatin (via P-gp and ABCG2 differential expression) in vitro.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/958
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4419
- Variant URL
- https://civic.genome.wustl.edu/links/variants/412
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Colon Cancer
- Evidence Direction
- Supports
- Drug
- Oxaliplatin
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 26398480
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Oxaliplatin | Resitance or Non-Reponse | true |