Annotation Detail
Information
- Associated Genes
- MAGEH1
- Associated Variants
-
MAGEH1 EXPRESSION
MAGEH1 EXPRESSION - Associated Disease
- bile duct adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- 10 biliary tract carcinoma cell lines were sorted based on their gemcitabine sensitivity. MAGEH1 protein expression was negatively correlated with sensitivity. In a clinical validation cohort, MAGEH protein expression was found in 4/4 "non-effective" cases and 2/5 effective cases based on RECIST criteria after gemcitabine treatment.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/950
- Gene URL
- https://civic.genome.wustl.edu/links/genes/11261
- Variant URL
- https://civic.genome.wustl.edu/links/variants/406
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Bile Duct Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Gemcitabine
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 20088962
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Gemcitabine | Resitance or Non-Reponse | true |