Annotation Detail
Information
- Associated Genes
- ABCB1
- Associated Variants
-
ABCB1 EXPRESSION
ABCB1 EXPRESSION - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- mRNA expression of ABCB1 in 17 NSCLC cell lines was associated with decreased response to paclitaxel (correlation of mRNA expression and paclitaxel IC50: r=0.5322, P=0.0279).
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/944
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4244
- Variant URL
- https://civic.genome.wustl.edu/links/variants/404
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Paclitaxel
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 21883677
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Resitance or Non-Reponse | true |