Annotation Detail
Information
- Associated Genes
- HSPB1
- Associated Variants
-
HSPB1 EXPRESSION
HSPB1 EXPRESSION - Associated Disease
- pancreatic ductal adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- HSP27 (HSPB1) expression in pancreatic adenocarcinoma cell lines was associated with sensitivity to treatment with gemcitabine.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/939
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2784
- Variant URL
- https://civic.genome.wustl.edu/links/variants/400
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Pancreatic Ductal Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Gemcitabine
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 22004109
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Gemcitabine | Sensitivity | true |