Annotation Detail
Information
- Associated Genes
- PTEN
- Associated Variants
-
PTEN DELETION
(
ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 ) - Associated Disease
- pancreatic carcinoma
- Source Database
- CIViC Evidence
- Description
- Among 33 patients treated with pan-AKT inhibitor MK-2206 in this phase 1 study, one patient with pancreatic adenocarcinoma and PTEN loss/KRAS G12D mutation experienced a decrease of approximately 60% in cancer antigen 19-9 levels and 23% shrinkage in tumor measurements.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/938
- Gene URL
- https://civic.genome.wustl.edu/links/genes/41
- Variant URL
- https://civic.genome.wustl.edu/links/variants/214
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Pancreatic Carcinoma
- Evidence Direction
- Supports
- Drug
- Akt Inhibitor MK2206
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 22025163
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Akt Inhibitor MK2206 | Sensitivity | true |