Annotation Detail
Information
- Associated Genes
- DUSP6
- Associated Variants
-
DUSP6 EXPRESSION
DUSP6 EXPRESSION - Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- Expression of DUSP6 was associated with sensitivity to MEK inhibitor GSK1120212 (Sensitivity: 79%; specificity: 82%: P = 0.0027) in 218 solid cancer cell lines.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/934
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1567
- Variant URL
- https://civic.genome.wustl.edu/links/variants/398
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Supports
- Drug
- Trametinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 22169769
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Trametinib | Sensitivity | true |