Annotation Detail
Information
- Associated Genes
- EIF4EBP1
- Associated Variants
-
EIF4EBP1 PHOSPHORYLATION
EIF4EBP1 PHOSPHORYLATION - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- 12 CRC cell lines were evaluated. 40% of these were intrinsically resistant to mTOR inhibition with BEZ235, PP242 or WYE354. mTOR independent phosphorylation of EIF4EBP1 (T37/46) was associated with resistance to mTOR inhibitors in one analyzed cell line (SW620).
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/932
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1655
- Variant URL
- https://civic.genome.wustl.edu/links/variants/387
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- MTOR Kinase Inhibitor PP242,WYE354,Dactolisib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 22262166
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dactolisib | Resitance or Non-Reponse | true |
| MTOR Kinase Inhibitor PP242 | Resitance or Non-Reponse | true |
| WYE354 | Resitance or Non-Reponse | true |