Annotation Detail

Information
Associated Genes
RPS6
Associated Variants
RPS6 PHOSPHORYLATION
RPS6 PHOSPHORYLATION
Associated Disease
gastric adenocarcinoma
Source Database
CIViC Evidence
Description
54 patients with advanced gastric cancer were treated with everolimus. Two patient responsed and potential biomarkers were explored. High pre-treatment expression of phosphorylated RPS6 (pS6; at Ser240/4) was associated with higher disease control rate and progression free survival (P=0.043, P=0.001 respectively; N=28).
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/930
Gene URL
https://civic.genome.wustl.edu/links/genes/5013
Variant URL
https://civic.genome.wustl.edu/links/variants/395
Rating
2
Evidence Type
Predictive
Disease
Gastric Adenocarcinoma
Evidence Direction
Supports
Drug
Everolimus
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
22343617
Drugs
Drug NameSensitivitySupported
EverolimusSensitivitytrue