Annotation Detail
Information
- Associated Genes
- TIMP1
- Associated Variants
-
TIMP1 OVEREXPRESSION
(
ENST00000218388.9 )
TIMP1 OVEREXPRESSION ( ENST00000218388.9 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- High expression of TIMP-1 was assessed by IHC in 99 primary breast cancers that had not spread beyond the breast after 6 postoperative courses of paclitaxel-based chemotherapy. High TIMP1 levels were associated with worse 5-year disease free survival (71.1%) than low levels (88.5 %; P = 0.020). High TIMP-1 levels were also associated with worse 5-year overall survival (78.9 %) than low levels (96.7 %; P = 0.004).
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/927
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5777
- Variant URL
- https://civic.genome.wustl.edu/links/variants/377
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Paclitaxel
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 22544540
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Resitance or Non-Reponse | true |