Annotation Detail
Information
- Associated Genes
- PROM1
- Associated Variants
-
PROM1 EXPRESSION
PROM1 EXPRESSION - Associated Disease
- hepatocellular carcinoma
- Source Database
- CIViC Evidence
- Description
- CD133 (PROM1) expression in 39 samples of hepatocellular carcinomas was correlated with JNK activity. Both were more highly expressed in patients not responding to sorafenib. CD133+ cells (sorted) were xenografted into mice, producing larger, more JNK inhibitor responsive tumors than CD133- xenografts.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/926
- Gene URL
- https://civic.genome.wustl.edu/links/genes/7014
- Variant URL
- https://civic.genome.wustl.edu/links/variants/393
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Hepatocellular Carcinoma
- Evidence Direction
- Supports
- Drug
- Sorafenib
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 22596232
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sorafenib | Resitance or Non-Reponse | true |