Annotation Detail
Information
- Associated Genes
- TUBB3
- Associated Variants
-
TUBB3 EXPRESSION
TUBB3 EXPRESSION - Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- High expression of class 3 beta-tubulin led to decreased effect of paclitaxel on cell motility in HeLa, MCF-7 and CHO cell lines.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/920
- Gene URL
- https://civic.genome.wustl.edu/links/genes/8262
- Variant URL
- https://civic.genome.wustl.edu/links/variants/389
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Supports
- Drug
- Paclitaxel
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 21576762
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Resitance or Non-Reponse | true |