Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
-
BRAF V600E AMPLIFICATION
(
ENST00000288602.11 )
BRAF V600E AMPLIFICATION ( ENST00000288602.11 ) - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- COLO201 and COLO206F cells harboring BRAF V600E mutations were cloned to be MEK inhibitor (AZD6244 [selumetinib]) resistant. The mechanism of this resistance was shown to be amplification of the BRAF V600E gene. BRAF V600E amplification was observed in 1/11 colorectal cancer patient samples evaluated, indicating this subclone (28% of cells) would be MEK inhibitor resistant.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/92
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5
- Variant URL
- https://civic.genome.wustl.edu/links/variants/14
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Selumetinib
- Evidence Level
- E
- Clinical Significance
- Resistance
- Pubmed
- 21098728
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Selumetinib | Resitance or Non-Reponse | true |