Annotation Detail
Information
- Associated Genes
- EIF4EBP1
- Associated Variants
-
EIF4EBP1 PHOSPHORYLATION
EIF4EBP1 PHOSPHORYLATION - Associated Disease
- gastric adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- 8 gastric cancer cell lines were treated with the MTOR inhibitor everolimus. Cell proliferation was effectively inhibited in 3 cell lines by everolimus. Phosphorylated EIF4EBP1 (T37/46, T70) levels were higher in cell lines and xenografts sensitive to everolimus.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/918
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1655
- Variant URL
- https://civic.genome.wustl.edu/links/variants/387
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Gastric Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Everolimus
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23340172
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Everolimus | Sensitivity | true |