Annotation Detail
Information
- Associated Genes
- EPHB4
- Associated Variants
-
EPHB4 EXPRESSION
EPHB4 EXPRESSION - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- EPHB4 expression, as assessed by quantitative RT-PCR in 13 colorectal cancer patients treated with bevacizumab, was higher in non-responders (p = 0.048). No difference was observed in a control group without bevacizumab treatment. qRT-PCR results were also shown to correlate with protein expression measured by IHC.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/905
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1721
- Variant URL
- https://civic.genome.wustl.edu/links/variants/381
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Bevacizumab
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 23579861
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Bevacizumab | Resitance or Non-Reponse | true |