Annotation Detail
Information
- Associated Genes
- TIMP1
- Associated Variants
-
TIMP1 OVEREXPRESSION
(
ENST00000218388.9 )
TIMP1 OVEREXPRESSION ( ENST00000218388.9 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- TIMP1 overexpression was associated with resistance to fulvestrant in breast cancer cell lines.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/901
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5777
- Variant URL
- https://civic.genome.wustl.edu/links/variants/377
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Fulvestrant
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 23881388
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fulvestrant | Resitance or Non-Reponse | true |