Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
-
EGFR EXON 18 OVEREXPRESSION
(
ENST00000344576.7 )
EGFR EXON 18 OVEREXPRESSION ( ENST00000344576.7 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Overexpression of EGFR exon 18 (Affymetrix Human Exon 1.0 ST) in tumor or blood samples was associated with tumor shrinkage, independently of EGFR mutational status in NSCLC treated with bevacizumab and erlotinib. 76 patients were analyzed for this study.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/898
- Gene URL
- https://civic.genome.wustl.edu/links/genes/19
- Variant URL
- https://civic.genome.wustl.edu/links/variants/375
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Erlotinib,Bevacizumab
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24039832
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Bevacizumab | Sensitivity | true |
| Erlotinib | Sensitivity | true |