Annotation Detail

Information
Associated Genes
FGFR1
Associated Variants
FGFR1 EXPRESSION
FGFR1 EXPRESSION
Associated Disease
colorectal cancer
Source Database
CIViC Evidence
Description
In vitro studies showed efficacy of FGFR inhibitor NVP-BGJ398 in cell lines exhibiting high FGFR1 protein. Three cell lines (SNU-C1, HDC9, HCT116) were analyzed. FGFR1 amplification (24/454, assessed by FISH) and/or activated pFGFR1 protein (18/99, assessed by mRNA in situ hybridization) was identified in primary CRC tissue samples.
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/896
Gene URL
https://civic.genome.wustl.edu/links/genes/1885
Variant URL
https://civic.genome.wustl.edu/links/variants/268
Rating
2
Evidence Type
Predictive
Disease
Colorectal Cancer
Evidence Direction
Supports
Drug
Infigratinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
24135816
Drugs
Drug NameSensitivitySupported
InfigratinibSensitivitytrue