Annotation Detail
Information
- Associated Genes
- PTEN
- Associated Variants
-
PTEN DELETION
(
ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 ) - Associated Disease
- endometrial cancer
- Source Database
- CIViC Evidence
- Description
- 94 endometrial cancer samples of women who had been treated with single agent mTOR inhibitors temsirolimus or ridaforolimus were retrospectively analyzed. No predictive biomarkers were identified, including PIK3CA mutations, KRAS mutations or PTEN loss.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/893
- Gene URL
- https://civic.genome.wustl.edu/links/genes/41
- Variant URL
- https://civic.genome.wustl.edu/links/variants/214
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Endometrial Cancer
- Evidence Direction
- Does Not Support
- Drug
- Temsirolimus,Ridaforolimus
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 24166148
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Ridaforolimus | Resitance or Non-Reponse | false |
| Temsirolimus | Resitance or Non-Reponse | false |