Annotation Detail
Information
- Associated Genes
- AGR2
- Associated Variants
-
AGR2 EXPRESSION
AGR2 EXPRESSION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- mRNA expression of AGR2 in 61 patients with tamoxifen treated postmenopausal breast cancer was determined by qRT-PCR and was inversely associated with treatment response and progression free survival (p= 0.0011, p = 0.0366 respectively). AGR2 protein expression as assessed by IHC was not significantly associated with treatment outcome.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/891
- Gene URL
- https://civic.genome.wustl.edu/links/genes/8407
- Variant URL
- https://civic.genome.wustl.edu/links/variants/373
- Rating
- 1
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Tamoxifen
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 24167368
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Tamoxifen | Resitance or Non-Reponse | true |