Annotation Detail
Information
- Associated Genes
- ATM
- Associated Variants
-
ATM UNDEREXPRESSION
(
ENST00000278616.10 )
ATM UNDEREXPRESSION ( ENST00000278616.10 ) - Associated Disease
- gastric adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- Low ATM protein expression led to sensitivity to PARP inhibitors in TP53 -ve gastric cancer cell lines (8 lines were used for various aspects of this study).
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/878
- Gene URL
- https://civic.genome.wustl.edu/links/genes/69
- Variant URL
- https://civic.genome.wustl.edu/links/variants/179
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Gastric Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Olaparib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24841718
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Olaparib | Sensitivity | true |