Annotation Detail

Information
Associated Genes
MRE11
Associated Variants
MRE11 LOSS ( ENST00000323929.8 )
MRE11 LOSS ( ENST00000323929.8 )
Associated Disease
endometrial cancer
Source Database
CIViC Evidence
Description
One endometrial cell line with decreased MRE11 expression caused by a homozygous poly(T) mutation exhibited increased sensitivity to the PARP inhibitor BMN-673. Loss of MRE11 was identified in 30.7% of endometrial tumors (N=521).
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/876
Gene URL
https://civic.genome.wustl.edu/links/genes/3586
Variant URL
https://civic.genome.wustl.edu/links/variants/370
Rating
2
Evidence Type
Predictive
Disease
Endometrial Cancer
Evidence Direction
Supports
Drug
Talazoparib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
24927325
Drugs
Drug NameSensitivitySupported
TalazoparibSensitivitytrue