Annotation Detail
Information
- Associated Genes
- ERBB4
- Associated Variants
-
ERBB4 EXPRESSION
ERBB4 EXPRESSION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- siRNA knockdown of HER4 or inhibition with neratinib enhanced trastuzumab response in breast cancer cell lines.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/868
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1734
- Variant URL
- https://civic.genome.wustl.edu/links/variants/365
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Trastuzumab
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 25153719
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Trastuzumab | Resitance or Non-Reponse | true |