Annotation Detail
Information
- Associated Genes
- ERBB4
- Associated Variants
-
ERBB4 NUCLEAR TRANSLOCATION
ERBB4 NUCLEAR TRANSLOCATION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- HER4 nuclear translocation was identified as a mediator of trastuzumab resistance in HER2 positive breast cancer cell lines. Increased nuclear staining was also identified in xenograft and patient samples after trastuzumab treatment.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/867
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1734
- Variant URL
- https://civic.genome.wustl.edu/links/variants/364
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Trastuzumab
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 25153719
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Trastuzumab | Resitance or Non-Reponse | true |