Annotation Detail
Information
- Associated Genes
- AR
- Associated Variants
-
AR SPLICE VARIANT 7
AR SPLICE VARIANT 7 - Associated Disease
- prostate cancer
- Source Database
- CIViC Evidence
- Description
- Detection of AR-V7 in circulating tumor cells of 62 patients treated with either enzalitamide (n=31) or arbiraterone (n=31), was correlated with lower PSA response rates and PSA PFS in men receiving enzalutamide or abiraterone.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/863
- Gene URL
- https://civic.genome.wustl.edu/links/genes/67
- Variant URL
- https://civic.genome.wustl.edu/links/variants/362
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Prostate Cancer
- Evidence Direction
- Supports
- Drug
- Abiraterone,Enzalutamide
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 25184630
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Abiraterone | Resitance or Non-Reponse | true |
| Enzalutamide | Resitance or Non-Reponse | true |