Annotation Detail
Information
- Associated Genes
- NRG1
- Associated Variants
-
NRG1 EXPRESSION
NRG1 EXPRESSION - Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- This screening study in various tumor xenografts identified NRG1 expression to correlate with sensivity to ERBB3 inhibitory antibody AV-203. ERBB3 expression was not predictive of response.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/861
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2593
- Variant URL
- https://civic.genome.wustl.edu/links/variants/314
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Supports
- Drug
- Anti-ErbB3 Monoclonal Antibody AV-203
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25542901
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Anti-ErbB3 Monoclonal Antibody AV-203 | Sensitivity | true |