Annotation Detail
Information
- Associated Genes
- CDKN1B
- Associated Variants
-
CDKN1B CYTOPLASMIC MISLOCALIZATION
CDKN1B CYTOPLASMIC MISLOCALIZATION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- Cytoplasmic localization of p27 (CDKN1B) leads to lapatinib resistance in HER2+ breast cancer cell lines. p27 knockout resensitiuzed cells to lapatinib.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/860
- Gene URL
- https://civic.genome.wustl.edu/links/genes/914
- Variant URL
- https://civic.genome.wustl.edu/links/variants/360
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Lapatinib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 25587029
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Lapatinib | Resitance or Non-Reponse | true |