Annotation Detail
Information
- Associated Genes
- RSF1
- Associated Variants
-
RSF1 AMPLIFICATION
(
ENST00000308488.11 )
RSF1 AMPLIFICATION ( ENST00000308488.11 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- In retrospective study, 413 patients were assessed for RSF1 amplification. 28 patients with RSF1 amplification did not show a benefit from adjuvant tamoxifen compared to placebo (12 treated vs 16 placebo). 381 patients without amplification did show a benefit compared to placebo (187 treated vs 194 placebo).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/857
- Gene URL
- https://civic.genome.wustl.edu/links/genes/12121
- Variant URL
- https://civic.genome.wustl.edu/links/variants/358
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Tamoxifen
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 24367492
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Tamoxifen | Resitance or Non-Reponse | true |