Annotation Detail

Information
Associated Genes
TP53
Associated Variants
TP53 DELETERIOUS MUTATION
TP53 DELETERIOUS MUTATION
Associated Disease
gastric adenocarcinoma
Source Database
CIViC Evidence
Description
In this meta-analysis of 13 studies (564 patients) p53 positivity as defined by high protein expression and/or p53 mutation was associated with improved response to chemotherapy (risk ratio [RR] = 0.704; 95% confidence intervals [CI] = 0.550-0.903; P = 0.006).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/850
Gene URL
https://civic.genome.wustl.edu/links/genes/45
Variant URL
https://civic.genome.wustl.edu/links/variants/222
Rating
3
Evidence Type
Predictive
Disease
Gastric Adenocarcinoma
Evidence Direction
Supports
Drug
Chemotherapy
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
24740294
Drugs
Drug NameSensitivitySupported
ChemotherapySensitivitytrue