Annotation Detail
Information
- Associated Genes
- BRCA1
- Associated Variants
-
BRCA1 LOSS-OF-FUNCTION
BRCA1 LOSS-OF-FUNCTION - Associated Disease
- prostate cancer
- Source Database
- CIViC Evidence
- Description
- 1/1 patients with BRCA1 homozygous deletion had a response to olaparib in this phase 2 study.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/845
- Gene URL
- https://civic.genome.wustl.edu/links/genes/6
- Variant URL
- https://civic.genome.wustl.edu/links/variants/131
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Prostate Cancer
- Evidence Direction
- Supports
- Drug
- Olaparib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26510020
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Olaparib | Sensitivity | true |