Annotation Detail
Information
- Associated Genes
- PBK
- Associated Variants
-
PBK OVEREXPRESSION
(
ENST00000301905.9 )
PBK OVEREXPRESSION ( ENST00000301905.9 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- TOPK (PBK) silencing sensitized lung cancer cells to gefitinib in preclinical xenograft models. Over-expression was also associated with resistance in various lung cancer cell lines.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/835
- Gene URL
- https://civic.genome.wustl.edu/links/genes/13276
- Variant URL
- https://civic.genome.wustl.edu/links/variants/348
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Gefitinib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 26745678
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Gefitinib | Resitance or Non-Reponse | true |