Annotation Detail
Information
- Associated Genes
- HMOX1
- Associated Variants
-
HMOX1 EXPRESSION
HMOX1 EXPRESSION - Associated Disease
- renal cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In 66 patients with advanced renal cell carcinoma, high expression of heme oxygenase-1 (HO-1) was associated with poor overall response rate (2.6% versus 53.6%, P<0.01), clinical benefit rate (47.4% versus 92.9%, P<0.01), shorter progression-free survival (4.4 versus 42 months, P=0.022) and poor overall survival (χ (2)=4.775, P=0.029) in patients receiving sorafenib or sunitinib.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/829
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2657
- Variant URL
- https://civic.genome.wustl.edu/links/variants/344
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Renal Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Sunitinib,Sorafenib
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 26309414